Early life experiences selectively mature learning and memory abilities.
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ABSTRACT:
SUBMITTER: Bessieres B
PROVIDER: S-EPMC6994621 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Early life experiences selectively mature learning and memory abilities.
Bessières Benjamin B Travaglia Alessio A Mowery Todd M TM Zhang Xinying X Alberini Cristina M CM
Nature communications 20200131 1
The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here we show that episodic learning produces unique biological changes in the hippocampus of infant rats and mice compared to juveniles and adults. These changes include persistent neuronal activation, BDNF-dependent increase in the excitatory synapse markers synaptophysin and PSD-95, and significant maturation of AMPA receptor synaptic responses. Inhibition of PSD-95 induction following learning imp ...[more]
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