Ontology highlight
ABSTRACT:
SUBMITTER: Horwitz JA
PROVIDER: S-EPMC6995008 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Horwitz Joshua A JA Jenni Simon S Harrison Stephen C SC Whelan Sean P J SPJ
Proceedings of the National Academy of Sciences of the United States of America 20200117 4
Nonsegmented negative-stranded (NNS) RNA viruses, among them the virus that causes rabies (RABV), include many deadly human pathogens. The large polymerase (L) proteins of NNS RNA viruses carry all of the enzymatic functions required for viral messenger RNA (mRNA) transcription and replication: RNA polymerization, mRNA capping, and cap methylation. We describe here a complete structure of RABV L bound with its phosphoprotein cofactor (P), determined by electron cryo-microscopy at 3.3 Å resolutio ...[more]