Ontology highlight
ABSTRACT:
SUBMITTER: Sun Z
PROVIDER: S-EPMC6995143 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Sun Zhongxing Z Zhang Yanjun Y Jia Junqi J Fang Yuan Y Tang Yin Y Wu Hongfei H Fang Dong D
Cell & bioscience 20200131
Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of genomic stability after DNA damage. There are diverse clues showing H3K36me3 participates in DNA damage response by directly recruiting DNA repair machinery to set the chromatin at a "ready" status, leading to a quick response upon damage. Reduced H3K36me3 is associated with low DNA repair eff ...[more]