Ontology highlight
ABSTRACT:
SUBMITTER: Ding S
PROVIDER: S-EPMC6995523 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Ding Sujuan S Xu Sheng S Ma Yong Y Liu Gang G Jang Hongmei H Fang Jun J
Biomolecules 20191209 12
The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1β, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation ...[more]