Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC6995615 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Lee Jong Hyun JH Mohan Chakrabhavi Dhananjaya CD Basappa Salundi S Rangappa Shobith S Chinnathambi Arunachalam A Alahmadi Tahani Awad TA Alharbi Sulaiman Ali SA Kumar Alan Prem AP Sethi Gautam G Ahn Kwang Seok KS Rangappa Kanchugarakoppal S KS
Biomolecules 20191213 12
STAT3 is an oncogenic transcription factor that regulates the expression of genes which are involved in malignant transformation. Aberrant activation of STAT3 has been observed in a wide range of human malignancies and its role in negative prognosis is well-documented. In this report, we performed high-throughput virtual screening in search of STAT3 signaling inhibitors using a cheminformatics platform and identified 2-Amino-6-[2-(Cyclopropylmethoxy)-6-Hydroxyphenyl]-4-Piperidin-4-yl Nicotinonit ...[more]