Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC6995653 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Chang C Liu Libangxi L Yang Minghui M Li Bin B Yi Jiarong J Ai Xuezheng X Zhang Yang Y Huang Bo B Li Changqing C Feng Chencheng C Zhou Yue Y
Cell division 20200201
<h4>Background</h4>The senescence of nucleus pulposus (NP) cells plays a vital role in the pathogenesis of intervertebral disc (IVD) degeneration (IDD). NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce premature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a crucial gene regulating cell senescence. The aim of this study was to investigate the roles of EZH2 in NOX4-induced NP cell senescence and a feedback loop between EZH2 and NOX4.<h4>Results</h4>The down ...[more]