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Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man.

ABSTRACT: To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y-maze sociability testing. This unique "sociophobia" acquisition could be documented in independent cohorts. We therefore employed infrared thermography as a non-invasive method of stress-monitoring during SocioBox testing (presentation of five other mice) versus empty box. A higher Centralization Index (body/tail temperature) in the SocioBox correlated negatively with social recognition memory and, after 4 weeks, with social preference in the Y-maze. Assuming that social stimuli might be associated with characteristic thermo-responses, we exposed healthy men (N = 103) with a comparably high intelligence level to a standardized test session including two cognitive tests with or without social component (face versus pattern recognition). In some analogy to the Centralization Index (within-subject measure) used in mice, the Reference Index (ratio nose/malar cheek temperature) was introduced to determine the autonomic facial response/flushing during social recognition testing. Whereas cognitive performance and salivary cortisol were comparable across human subjects and tests, the Face Recognition Test was associated with a characteristic Reference Index profile. Infrared thermography may have potential for discriminating disturbed social behaviors.

SUBMITTER: Seidel J

PROVIDER: S-EPMC6996302 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man.

Seidel Jan J Bockhop Fabian F Mitkovski Miso M Martin Sabine S Ronnenberg Anja A Krueger-Burg Dilja D Schneider Katharina K Röhse Heiko H Wüstefeld Liane L Cosi Filippo F Bröking Kai K Schacht Annekathrin A Ehrenreich Hannelore H

FASEB bioAdvances 20191223 1

To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y-maze sociability testing. This unique "sociophobia" acquisition could be documented in independent cohorts. We therefore employed infrared thermography as a non-invasive method of stress-monitoring during SocioBox testing (presentation of five other mice) versus empty box. A higher ...[more]

PMID: 32123854

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Project description:Hypothermia is risk factor for piglet neonatal mortality, especially for low birth weight piglets. Piglets with intrauterine growth retardation (IUGR) also have a higher mortality risk at birth. This study aimed to validate infrared thermography (IRT) as an alternative to rectal temperature (RT) to measure piglet temperature in the hour postpartum, and to identify piglets with thermoregulation difficulties. At birth (6.3 ± 0.35 min postpartum), 67 piglets were dried, weighed, scored for growth retardation (IUGR; 0-3), and isolated in a plastic box where IRT images were taken, followed by RT. Piglets were then returned to the farrowing pen, and the process repeated at 15, 30, and 60 min postpartum. Piglets were ranked according to their weight (quartiles: 0.57-1.27 kg, 1.27-1.5 kg, 1.5-1.74 kg, 1.74-2.44 kg). Temperatures (ear base and tip; minimum, maximum and average of back) were extracted from IRT images (Thermacam Researcher Pro 2.0). Pearson correlations between temperature measures were calculated, and the effect of time, IUGR score, and weight were included in linear mixed models (SAS 9.4). RT was correlated with all IRT data across time points (P < 0.05); correlations were strongest with the ear base, and weakest with the ear tip and minimum back temperature. Both IUGR score and weight rank affected ear base (P < 0.05) and RTs (P < 0.05). The lightest piglets, and piglets with severe IUGR had the lowest temperature, relative to their counterparts. Indeed, differences between all weights categories were significant for RT. Piglets with the lowest weight (0.27-1.27 kg) had lower ear base temperatures than piglets in the third quartile (1.5-1.74 kg; 35.2 ± 0.36 °C vs. 36.5 ± 0.35 °C, t 64.9 = -4.51, P < 0.001) and the heaviest piglets (1.74-2.44 kg; 35.2 ± 0.36 °C vs. 36.4 ± 0.36 °C, t 70.4 = -3.97, P < 0.005). Overall, piglets with severe IUGR (score 3) had a lower RT than normal piglets (score 0; 35.8 ± 0.46 °C vs. 37.2 ± 0.42 °C, t 43.1 = 3.16, P < 0.05) and piglets with mild IUGR (score 1; 35.8 ± 0.46 °C vs. 37.1 ± 0.40 °C, t 45.3 = 2.92, P < 0.05); and they also had lower temperature at the base of the ear than normal piglets (35.1 ± 0.42 °C vs. 36.3 ± 0.36 °C, t 63.1 = 3.01, P < 0.05). These results confirmed that IRT is an interesting noninvasive tool for assessing neonatal piglets' thermoregulatory abilities and could be used in research investigating successful interventions for piglets at risk of hypothermia.

Dataset Information

Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man.

Publications

Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man.

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