Ontology highlight
ABSTRACT:
SUBMITTER: Shi K
PROVIDER: S-EPMC6996314 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Shi Ke K Demir Özlem Ö Carpenter Michael A MA Banerjee Surajit S Harki Daniel A DA Amaro Rommie E RE Harris Reuben S RS Aihara Hideki H
FASEB bioAdvances 20191224 1
The single-stranded DNA cytosine deaminase APOBEC3B (A3B) functions in innate immunity against viruses, but it is also strongly implicated in eliciting mutations in cancer genomes. Because of the critical role of A3B in promoting virus and tumor evolution, small molecule inhibitors are desirable. However, there is no reported structure for any of the APOBEC3-family enzymes in complex with a small molecule bound in the active site, which hampers the development of small molecules targeting A3B. H ...[more]