Ontology highlight
ABSTRACT:
SUBMITTER: Burat B
PROVIDER: S-EPMC6996406 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Burat Bastien B Faucher Quentin Q Čechová Petra P Arnion Hélène H Di Meo Florent F Sauvage François-Ludovic FL Marquet Pierre P Essig Marie M
FASEB bioAdvances 20190824 9
Calcineurin inhibitors (CNI) are the pillars of immunosuppression in transplantation. However, they display a potent nephrotoxicity whose mechanisms remained widely unsolved. We used an untargeted quantitative proteomic approach (iTRAQ technology) to highlight new targets of CNI in renal proximal tubular cells (RPTCs). CNI-treated RPTCs proteome displayed an over-representation of actin-binding proteins with a CNI-specific expression profile. Cyclosporine A (CsA) induced F-actin remodeling and d ...[more]