Ontology highlight
ABSTRACT:
SUBMITTER: Kim KH
PROVIDER: S-EPMC6996546 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Kim Kyung Hun KH Lim Seo Hyun SH Shim Cho Rok CR Park Junsung J Song Woo Heon WH Kwon Min Chang MC Lee Jong Hyuk JH Park Jun Sang JS Choi Han-Gon HG
Drug design, development and therapy 20200130
<h4>Background</h4>Novel three-layered (TL) tablet systems were compared with both monolithic matrix (MM) formulations and a commercial immediate-release (IR) capsule to develop once-a-day (OAD) pregabalin tablets.<h4>Methods</h4>The physical properties of the TL tablets, including dissolution and swelling rates, were compared with those of the MM tablets and the pharmacokinetic parameters of the TL tablet were compared with those of an IR capsule in beagles and humans.<h4>Results</h4>Our result ...[more]