Immune response to influenza vaccination in ESRD patients undergoing hemodialysis vs. hemodiafiltration.

ABSTRACT:

Background

On-line hemodiafiltration (HDF) clears more azotemic toxins compared to high-flux hemodialysis (HD). The response to vaccination is impaired in dialysis patients. We wished to determine whether the immune responses to influenza vaccine in dialysis patients treated by HDF were stronger than those treated by HD.

Materials and methods

We conducted a prospective cohort study in chronic dialysis patients during the 2016 and 2017 influenza seasons. All participants received a single standard dose of trivalent influenza vaccine, and we studied the elicited humoral immune response by hemagglutination inhibition test, and cell-mediated immune response by enumeration of lymphocyte cellular markers and proliferation assays.

Results

We immunized 60 end-stage renal dise

SUBMITTER: Nongnuch A 

PROVIDER: S-EPMC6996846 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature