Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer.

ABSTRACT:

Background

Na⁺ /H⁺ exchanger regulatory factor 1 (NHERF1) has been implicated in the tumorigenesis of several cancer types and is a potential therapeutic target. The current study evaluated the relationship between NHERF1 expression and clinical outcome in colorectal cancer (CRC).

Methods

NHERF1 expression was evaluated by immunohistochemistry in 167 patients with CRC primary tumors, 37 patients with no disease, and 27 patients with metastatic CRC (mCRC); and in the orthotopically implanted tumors in mice. NHERF1 expression was manipulated in CRC cells using inducible short hairpin RNAs to determine its biological functions.

Results

High expression of NHERF1 correlated with CRC progression and metastasis, as well as significantly worse overall su

SUBMITTER: Leiphrakpam PD 

PROVIDER: S-EPMC6996851 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature