Ontology highlight
ABSTRACT:
SUBMITTER: Kierdorf K
PROVIDER: S-EPMC6996930 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kierdorf Katrin K Hersperger Fabian F Sharrock Jessica J Vincent Crystal M CM Ustaoglu Pinar P Dou Jiawen J Gyoergy Attila A Groß Olaf O Siekhaus Daria E DE Dionne Marc S MS
eLife 20200120
<i>Unpaired</i> ligands are secreted signals that act via a GP130-like receptor, <i>domeless</i>, to activate JAK/STAT signalling in <i>Drosophila</i>. Like many mammalian cytokines, <i>unpaireds</i> can be activated by infection and other stresses and can promote insulin resistance in target tissues. However, the importance of this effect in non-inflammatory physiology is unknown. Here, we identify a requirement for <i>unpaired</i>-JAK signalling as a metabolic regulator in healthy adult <i>Dro ...[more]