Pulmonary function decreases moderately after accelerated high-dose irradiation for stage III non-small cell lung cancer.

ABSTRACT:

Background

Chemoradiotherapy (CRT) is the standard treatment for patients with inoperable stage III non-small cell lung cancer (NSCLC) stage III. With a median OS beyond 30 months, adequate pulmonary function (PF) is essential to ensure acceptable quality of life after treatment. Forced expiratory volume in 1 second (FEV1) and diffusing capacity of the lung for carbon monoxide (DLCO) are the most widely used parameters to assess lung function. The aim of the current study was to evaluate dose-volume effects of accelerated high-dose radiation on PF.

Methods

A total of 72 patients were eligible for the current analysis. After induction chemotherapy, all patients received dose-differentiated accelerated radiotherapy with intensity-modulated radiotherapy (IMRT-DART). PF tests we

SUBMITTER: Grambozov B 

PROVIDER: S-EPMC6996983 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature