Dataset Information

Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Gottingen Minipigs.

ABSTRACT: Background/objectives: Cholecystokinin (CCK) is a regulator of appetite and energy intake in man. The aim of this study was to determine the effect of NN9056, a long-acting CCK-1 receptor-selective CCK analogue, on food intake and body weight (BW) in obese Göttingen Minipigs.

Subjects/methods: Tolerability of NN9056 and acute effects on food intake, pancreas histology, amylase and lipase levels were assessed in lean domestic pigs in doses up to 100?nmol/kg (n?=?3-4). Subsequently, obese Göttingen Minipigs were treated subcutaneously (s.c.) once daily for 13 weeks with vehicle, NN9056 low dose (regulated from 5 to 2?nmol/kg) or NN9056 high dose (10?nmol/kg) (n?=?7-8). Food intake was measured daily and BW twice weekly. At the end of the treatment period, an intravenous glucose tolerance test (IVGTT) and a 24-h exposure profile was obtained. Data are mean?±?SD.

Results: The acute studies in domestic pigs showed significant and dose-dependent effect of NN9056 on food intake, acceptable tolerability and no histopathological signs of pancreatitis. Sub-chronic treatment in obese Göttingen Minipigs was also well tolerated and accumulated food intake was significantly lower in both treated groups compared to vehicle, with no significant difference between the dose levels of NN9056 (41.8?±?12.6, 51.5?±?13.8 and 86.5?±?19.5?kg in high-dose, low-dose and vehicle groups, respectively, p?=?0.012 and p?
Conclusion: NN9056, a long-acting CCK-1 receptor-selective CCK analogue, significantly reduced food intake and BW in obese Göttingen Minipigs after once daily s.c. dosing for 13 weeks.

SUBMITTER: Christoffersen BO

PROVIDER: S-EPMC6997118 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs.

Christoffersen Berit Ø BØ Skyggebjerg Rikke Bjerring RB Bugge Anne A Kirk Rikke Kaae RK Vestergaard Bill B Uldam Henriette Kold HK Fels Johannes Josef JJ Pyke Charles C Sensfuss Ulrich U Sanfridson Annika A Clausen Trine Ryberg TR

International journal of obesity (2005) 20190607 2

<h4>Background/objectives</h4>Cholecystokinin (CCK) is a regulator of appetite and energy intake in man. The aim of this study was to determine the effect of NN9056, a long-acting CCK-1 receptor-selective CCK analogue, on food intake and body weight (BW) in obese Göttingen Minipigs.<h4>Subjects/methods</h4>Tolerability of NN9056 and acute effects on food intake, pancreas histology, amylase and lipase levels were assessed in lean domestic pigs in doses up to 100 nmol/kg (n = 3-4). Subsequently, o ...[more]

PMID: 31175319

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Dataset Information

Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Gottingen Minipigs.

Publications

Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs.

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