Ontology highlight
ABSTRACT:
SUBMITTER: Qu P
PROVIDER: S-EPMC6997156 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Qu Panke P Zhang Chao C Li Min M Ma Weimin W Xiong Pei P Liu Qingwei Q Zou Gang G Lavillette Dimitri D Yin Feifei F Jin Xia X Huang Zhong Z
Cell discovery 20200204
Zika virus (ZIKV) infection poses a serious threat to human health. However, no licensed vaccine or therapeutic drug is currently available for ZIKV. We have previously shown that recombinant ZIKV E80 protein induced potent neutralizing antibody response and protected mice from lethal viral challenge. In the present study, we isolated five ZIKV neutralizing monoclonal antibodies (mAbs) from E80-immunized mice. These five mAbs specifically bound and neutralized Asian-lineage ZIKV strains. Epitope ...[more]