The effect of spontaneous osteoarthritis on conditioned pain modulation in the canine model.
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ABSTRACT:
SUBMITTER: Chiu KW
PROVIDER: S-EPMC6997173 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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The effect of spontaneous osteoarthritis on conditioned pain modulation in the canine model.
Chiu King Wa KW Hash Jon J Meyers Rachel R Lascelles B Duncan X BDX
Scientific reports 20200203 1
Endogenous Pain Modulation (EPM) impairment is a significant contributor to chronic pain. Conditioned pain modulation (CPM) testing assesses EPM function. Osteoarthritic (OA) dogs are good translational models, but CPM has not been explored. Our aim was to assess EPM impairment in OA dogs compared to controls using CPM. We hypothesized that CPM testing would demonstrate EPM impairment in OA dogs compared to controls. Dogs with stifle/hip OA and demographically-matched controls were recruited. Th ...[more]
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