Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice.
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ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC6997184 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice.
Lu Zongyang Z Liu Zhen Z Mao Wei W Wang Xinying X Zheng Xiaoguo X Chen Shanshan S Cao Beibei B Huang Shisheng S Zhang Xuliang X Zhou Tao T Zhang Yu Y Huang Xingxu X Sun Qiang Q Li Jia-Da JD
Cell death & disease 20200203 2
Autism spectrum disorder (ASD) is a neurodevelopmental disease with a strong heritability, but recent evidence suggests that epigenetic dysregulation may also contribute to the pathogenesis of ASD. Especially, increased methylation at the MECP2 promoter and decreased MECP2 expression were observed in the brains of ASD patients. However, the causative relationship of MECP2 promoter methylation and ASD has not been established. In this study, we achieved locus-specific methylation at the transcrip ...[more]
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