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Immunotherapy for the Treatment of Breast Cancer: Emerging New Data.

ABSTRACT: Breast cancer is the most common type of cancer affecting women in the United States. Triple-negative breast cancer remains the most aggressive molecular subtype secondary to a lack of therapeutic targets. The search for a target has led us to investigate immunotherapeutic agents. Immunotherapy has recently demonstrated significant breakthroughs in various types of cancers that are refractory to traditional therapies including melanoma and Non-Small Cell Lung Cancer (NSCLC). Breast cancer however remains one of the tumors that was initially least investigated because of being considered to have a low immunogenic potential and a low mutational load. Over the past few years, antiPD1/PDL1 drugs have started to make progress in the triple-negative subtype with more promising outcomes. In this report, we review the treatment of triple-negative breast cancer and specifically shed light on advances in immunotherapy and newly approved drugs in this challenging disease.

SUBMITTER: Mina LA

PROVIDER: S-EPMC6997226 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Immunotherapy for the Treatment of Breast Cancer: Emerging New Data.

Mina Lida A LA Lim Shannon S Bahadur Shakeela W SW Firoz Abdul T AT

Breast cancer (Dove Medical Press) 20191231

Breast cancer is the most common type of cancer affecting women in the United States. Triple-negative breast cancer remains the most aggressive molecular subtype secondary to a lack of therapeutic targets. The search for a target has led us to investigate immunotherapeutic agents. Immunotherapy has recently demonstrated significant breakthroughs in various types of cancers that are refractory to traditional therapies including melanoma and Non-Small Cell Lung Cancer (NSCLC). Breast cancer howeve ...[more]

PMID: 32099454

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