Ontology highlight
ABSTRACT:
SUBMITTER: Feng Y
PROVIDER: S-EPMC6997366 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Feng Yilu Y Zhang Ye Y Cai Yi Y Liu Ruijie R Lu Miaolong M Li Tangzhiming T Fu Ying Y Guo Ming M Huang Huichao H Ou Yifu Y Chen Yongheng Y
Cell death & disease 20200203 2
Abnormal expression of the E3 ubiquitin ligase A20 has been found in some malignant cancers, including hepatocellular carcinoma (HCC). Here, we discovered that A20 is an E3 ubiquitin ligase for phosphofructokinase, liver type (PFKL) in HCC A20 interacts with PFKL and promotes its degradation, therefore inhibiting glycolysis in HCC cell lines. Downregulation of A20 in HCC cells promotes proliferation, migration, and glycolysis, all of which can be inhibited by targeting PFKL with RNA interference ...[more]