Down-regulation of argininosuccinate lyase induces hepatoma cell apoptosis through activating Bax signaling pathway.
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ABSTRACT:
SUBMITTER: Gong R
PROVIDER: S-EPMC6997574 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Down-regulation of argininosuccinate lyase induces hepatoma cell apoptosis through activating Bax signaling pathway.
Gong Rui R He Lin L Zhou HongZhong H Cheng ShengTao S Ren Fang F Chen Juan J Ren JiHua J
Genes & diseases 20181128 3
Argininosuccinate lyase (ASL) plays an important role in the hepatic urea cycle, and can catalyze the reversible reaction of argininosuccinate to arginine and fumarate. However, the function of ASL in hepatocellular carcinoma (HCC) is not fully understood. In this study, we found that ASL expression was frequently upregulated in HCC tissues and HCC cell lines. Knock down of ASL inhibited cell proliferation and induced apoptosis in HCC cells. Mechanistic studies revealed the BCL2-associated X pro ...[more]
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