Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi S
PROVIDER: S-EPMC6997815 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Hayashi Soichiro S Osada Yoshiyuki Y Miura Kazuki K Simizu Siro S
Biochemistry and biophysics reports 20200130
Vasculogenic mimicry (VM) promotes tumor migration, metastasis, and invasion in various types of cancer, but the relationship between VM and these phenotypes remains undefined. In this study, we examined carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) as a novel target of VM. We found that ectopic expression of CEACAM1 in HT1080 human fibrosarcoma cells suppressed the formation of a VM-like network. Further, cell migration and proliferation were abated by the introduction of CEACAM1 ...[more]