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Molecular perspective and anticancer activity of medicinal plants.


ABSTRACT: To evaluate phytochemical constituents from the methanolic extracts of medicinal plants Aloe castellorum and Aloe pseudorubroviolacea. The cytotoxic activity of Aloe castellorum and Aloe pseudorubroviolacea leaf extracts against Human colon cancer cell line (HCT-116) was also assessed. The two medicinal plant extracts having significant cytotoxic activity, meanwhile the methanolic extract of Aloe castellorum shows higher cytotoxic activity than Aloe pseudorubroviolacea extract. The Aloe castellorum shows remarkable activity against respective cell line than control. The characteristic chemical constituents of Aloe castellorum and Aloe pseudorubroviolacea leaf extracts were recognized from Gas chromatography and Mass spectrometry (GC-MS) technique. The molecular docking studies also support the cytotoxic activity.

SUBMITTER: Ahamed A 

PROVIDER: S-EPMC6997859 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Molecular perspective and anticancer activity of medicinal plants.

Ahamed Anis A   Panneerselvam A A   Alaklabi Abdullah A   Arif Ibrahim A IA   Ambikapathy V V   Thajuddin N N  

Saudi journal of biological sciences 20191217 2


To evaluate phytochemical constituents from the methanolic extracts of medicinal plants <i>Aloe castellorum</i> and <i>Aloe pseudorubroviolacea</i>. The cytotoxic activity of <i>Aloe castellorum</i> and <i>Aloe pseudorubroviolacea</i> leaf extracts against Human colon cancer cell line (HCT-116) was also assessed. The two medicinal plant extracts having significant cytotoxic activity, meanwhile the methanolic extract of <i>Aloe castellorum</i> shows higher cytotoxic activity than <i>Aloe pseudoru  ...[more]

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