Screening and Functional Analysis of Hub MicroRNAs Related to Tumor Development in Colon Cancer.
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ABSTRACT:
SUBMITTER: Yu DH
PROVIDER: S-EPMC6998761 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Screening and Functional Analysis of Hub MicroRNAs Related to Tumor Development in Colon Cancer.
Yu Dong-Hu DH Li Wei W Huang Jing-Yu JY Liu Xiao-Ping XP Zhang Chi C Ruan Xiao-Lan XL Li Sheng S
BioMed research international 20200123
Various microRNAs (miRNAs) are of importance in the development of colon cancer, but most of the mechanisms of the miRNAs are still unclear. In order to clarify the hub miRNAs and their roles in colon cancer development, GSE98406 was used to screen hub miRNAs by bioinformatics analysis. 46 DE-miRNAs (14 were upregulated and 32 were downregulated) and 1738 target genes of DE-miRNAs were ascertained. miRNAs-gene-networks and miRNAs-GO-networks were built to get more knowledge about the function of ...[more]
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