Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss.

ABSTRACT: BACKGROUND:Noise-induced hearing loss (NIHL) is a complex disease caused by environmental and genetic risk factors. This study was to explore the association of noise kurtosis, triphosphopyridine nucleotide oxidase 3 (NOX3) and lifestyles with NIHL. METHODS:This case-control study included 307 patients with NIHL and 307 matched control individuals from Zhejiang province of China. General characteristics, noise exposure data, the exfoliated cells of the oral mucosa, and lifestyle details of individuals were collected. The kompetitive allele specific polymerase chain reaction (KASP) method was used to analyze the genotypes of three single nucleotide polymorphisms (SNPs) of NOX3. RESULTS:People who exposed to complex noise had a higher risk of NIHL than those exposed to steady noise (adjusted: OR?=?1.806, P =?0.002). The GT genotype of additive model and TT?+?GT genotype of dominant model in NOX3 rs12195525 decreased the risk of NIHL (adjusted: OR?=?0.618, P =?0.043; OR?=?0.622, P =?0.036). Smoking and exposure to high video volume increased the risk of NIHL (adjusted: OR?=?1.486, P =?0.038; OR?=?1.611, P =?0.014). Oppositely, regular physical exercise decreased the risk of NIHL (adjusted: OR?=?0.598, P =?0.004). A positive interaction was found between complex noise and lifestyles including high video volume exposure and no physical exercise in the additive models (RERI?=?1.088, P 

SUBMITTER: Zhao T 

PROVIDER: S-EPMC6998835 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature