Differences Between Human and Murine Tau at the N-terminal End.
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ABSTRACT:
SUBMITTER: Hernandez F
PROVIDER: S-EPMC6999090 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Differences Between Human and Murine Tau at the N-terminal End.
Hernández Félix F Merchán-Rubira Jesús J Vallés-Saiz Laura L Rodríguez-Matellán Alberto A Avila Jesús J
Frontiers in aging neuroscience 20200128
Human tauopathies, such as Alzheimer's disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the two species differs. Tau 3R isoforms are not present in adult mice. In contrast, the adult human brain contains Tau 3R and also Tau 4R isoforms. In addition, the N-terminal sequence of Tau protein in ...[more]
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