Ontology highlight
ABSTRACT:
SUBMITTER: Zahoor A
PROVIDER: S-EPMC6999389 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zahoor Ahmed A Küttner Felix T F FTF Blank Lars M LM Ebert Birgitta E BE
Engineering in life sciences 20190829 10
Dicarboxylic acids are important bio-based building blocks, and <i>Saccharomyces cerevisiae</i> is postulated to be an advantageous host for their fermentative production. Here, we engineered a pyruvate decarboxylase-negative <i>S. cerevisiae</i> strain for succinic acid production to exploit its promising properties, that is, lack of ethanol production and accumulation of the precursor pyruvate. The metabolic engineering steps included genomic integration of a biosynthesis pathway based on the ...[more]