Ontology highlight
ABSTRACT:
SUBMITTER: Weber LK
PROVIDER: S-EPMC6999473 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Weber Laura K LK Isse Awale A Rentschler Simone S Kneusel Richard E RE Palermo Andrea A Hubbuch Jürgen J Nesterov-Mueller Alexander A Breitling Frank F Loeffler Felix F FF
Engineering in life sciences 20170720 10
Lyme disease is the most common tick-borne infectious disease in Europe and North America. Previous studies discovered the immunogenic role of a surface-exposed lipoprotein (VlsE) of <i>Borreliella burgdorferi</i>. We employed high density peptide arrays to investigate the antibody response to the VlsE protein in VlsE-positive patients by mapping the protein as overlapping peptides and subsequent in-depth epitope substitution analyses. These investigations led to the identification of antibody f ...[more]