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Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice.

ABSTRACT: Renal and cardiovascular complications of prematurity are well established, notably the development of hypertension in adulthood. However, the underlying molecular mechanisms remain poorly understood. Our objective was to investigate the impact of prematurity on the ontogenesis of renal corticosteroid pathways, to evaluate its implication in perinatal renal complications and in the emergence of hypertension in adulthood. Swiss CD1 pregnant mice were injected with lipopolysaccharides at 18 days of gestation (E18) to induce prematurity at E18.5. Pups were sacrificed at birth, 7 days and 6 months of life. Second (F2) and third (F3) generations, established by mating prematurely born adult females with wild-type males, were also analyzed. Former preterm males developed hypertension at M6 (P?

SUBMITTER: Dumeige L

PROVIDER: S-EPMC7000670 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice.

Dumeige Laurence L Nehlich Mélanie M Viengchareun Say S Perrot Julie J Pussard Eric E Lombès Marc M Martinerie Laetitia L

Experimental & molecular medicine 20200124 1

Renal and cardiovascular complications of prematurity are well established, notably the development of hypertension in adulthood. However, the underlying molecular mechanisms remain poorly understood. Our objective was to investigate the impact of prematurity on the ontogenesis of renal corticosteroid pathways, to evaluate its implication in perinatal renal complications and in the emergence of hypertension in adulthood. Swiss CD1 pregnant mice were injected with lipopolysaccharides at 18 days o ...[more]

PMID: 31974504

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