Ontology highlight
ABSTRACT:
SUBMITTER: Oshidari R
PROVIDER: S-EPMC7000754 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature communications 20200204 1
Cellular processes are influenced by liquid phase separation, but its role in DNA repair is unclear. Here, we show that in Saccharomyces cerevisiae, liquid droplets made up of DNA repair proteins cooperate with different types of DNA damage-inducible intranuclear microtubule filaments (DIMs) to promote the clustering of DNA damage sites and maintain genome stability. Rad52 DNA repair proteins at different DNA damage sites assemble in liquid droplets that fuse into a repair centre droplet via the ...[more]