Ontology highlight
ABSTRACT:
SUBMITTER: Hikida T
PROVIDER: S-EPMC7000772 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hikida Takatoshi T Yao Shuhei S Macpherson Tom T Fukakusa Ayumi A Morita Makiko M Kimura Haruhide H Hirai Keisuke K Ando Tatsuya T Toyoshiba Hiroyoshi H Sawa Akira A
Scientific reports 20200204 1
The medial prefrontal cortex (mPFC) is a critical component of a cortico-basal ganglia-thalamo-cortical loop regulating limbic and cognitive functions. Within this circuit, two distinct nucleus accumbens (NAc) output neuron types, dopamine D1 or D2 receptor-expressing neurons, dynamically control the flow of information through basal ganglia nuclei that eventually project back to the mPFC to complete the loop. Thus, chronic dysfunction of the NAc may result in mPFC transcriptomal changes, which ...[more]