Dietary quality indices modifies the effects of melanocortin-4 receptor (MC4R) rs17782313 polymorphism on cardio-metabolic risk factors and hypothalamic hormones in obese adults.

ABSTRACT: BACKGROUND:Although the Melanocortin-4 Receptor (MC4R) gene rs17782313 C/T has been consistently related to obesity risk, the interaction between MC4R polymorphism and diet quality indices on cardio-metabolic risk factors has not yet investigated. Therefore we aimed to test this hypothesis. METHODS:This cross-sectional study recruited 188 (96 males and 92 females) healthy obese adults aged 20-50?years. Diet quality indices including Healthy Eating Index-2015 (HEI-2015) and Diet Quality Index-International (DQI-I) were constructed using data from a validated food frequency questionnaire. MC4R s17782313 were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The interaction between MC4R polymorphism and diet quality indices was tested by Analysis of covariance (ANCOVA) multivariate interaction model. RESULTS:There were significant gene-diet interactions between rs17782313 and HEI-2015 (P Interaction 

SUBMITTER: Khodarahmi M 

PROVIDER: S-EPMC7001213 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature