Ontology highlight
ABSTRACT:
SUBMITTER: Maeda S
PROVIDER: S-EPMC7001313 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Maeda Sachi S Ohka Fumiharu F Okuno Yusuke Y Aoki Kosuke K Motomura Kazuya K Takeuchi Kazuhito K Kusakari Hironao H Yanagisawa Nobuyuki N Sato Shinya S Yamaguchi Junya J Tanahashi Kuniaki K Hirano Masaki M Kato Akira A Shimizu Hiroyuki H Kitano Yotaro Y Yamazaki Shintaro S Yamashita Shinji S Takeshima Hideo H Shinjo Keiko K Kondo Yutaka Y Wakabayashi Toshihiko T Natsume Atsushi A
Acta neuropathologica communications 20200205 1
Diffuse midline glioma, H3 K27M-mutant is a lethal brain tumor located in the thalamus, brain stem, or spinal cord. H3 K27M encoded by the mutation of a histone H3 gene such as H3F3A plays a pivotal role in the tumorigenesis of this type of glioma. Although several studies have revealed comprehensive genetic and epigenetic profiling, the prognostic factors of these tumors have not been identified to date. In various cancers, oncogenic driver genes have been found to exhibit characteristic copy n ...[more]