Ontology highlight
ABSTRACT:
SUBMITTER: Dirck AT
PROVIDER: S-EPMC7001482 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Dirck Aaron T AT Whyte Melissa L ML Hudson Amy W AW
Molecular biology of the cell 20191218 3
The human herpesvirus-7 (HHV-7) U21 glycoprotein binds to class I major histocompatibility complex (MHC) molecules in the endoplasmic reticulum (ER) and reroutes them to lysosomes. How this single viral glycoprotein efficiently redirects the U21/class I MHC complex to the lysosomal compartment is poorly understood. To investigate the trafficking of HHV-7 U21, we followed synchronous release of U21 from the ER as it traffics through the secretory system. Sorting of integral membrane proteins from ...[more]