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Scopoletin ameliorates anxiety-like behaviors in complete Freund's adjuvant-induced mouse model.

ABSTRACT: Anxiety disorder is highly prevalent worldwide and represents a chronic and functionally disabling condition, with high levels of psychological stress characterized by cognitive and physiological symptoms. Scopoletin (SP), a main active compound in Angelica dahurica, is traditionally used for the treatment of headache, rhinitis, pain, and other conditions. Here, we evaluated the effects of SP in a mouse model of complete Freund's adjuvant (CFA)-induced chronic inflammation anxiety. SP (2.0, 10.0, 50.0?mg/kg) administration for 2?weeks dose-dependently ameliorated CFA-induced anxiety-like behaviors in the open field test and elevated plus maze test. Moreover, we found that SP treatment inhibited microglia activation and decreased both peripheral and central IL-1?, IL-6, and TNF-? levels in a dose-dependent manner. Additionally, the imbalance in excitatory/inhibitory receptors and neurotransmitters in the basolateral nucleus after CFA injection was also modulated by SP administration. Our findings indicate that the inhibition of the nuclear factor-kappa B and mitogen-activated protein kinase signaling pathways involving anti-inflammatory activities and regulation of the excitatory/inhibitory balance can be attributed to the anxiolytic effects of SP. Moreover, our molecular docking analyses show that SP also has good affinity for gamma-aminobutyric acid (GABA) transaminase and GABAA receptors. Therefore, these results suggest that SP could be a candidate compound for anxiolytic therapy and for use as a structural base for developing new drugs.

SUBMITTER: Luo L

PROVIDER: S-EPMC7001522 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Scopoletin ameliorates anxiety-like behaviors in complete Freund's adjuvant-induced mouse model.

Luo Li L Sun Ting T Yang Le L Liu An A Liu Qing-Qing QQ Tian Qin-Qin QQ Wang Yan Y Zhao Ming-Gao MG Yang Qi Q

Molecular brain 20200204 1

Anxiety disorder is highly prevalent worldwide and represents a chronic and functionally disabling condition, with high levels of psychological stress characterized by cognitive and physiological symptoms. Scopoletin (SP), a main active compound in Angelica dahurica, is traditionally used for the treatment of headache, rhinitis, pain, and other conditions. Here, we evaluated the effects of SP in a mouse model of complete Freund's adjuvant (CFA)-induced chronic inflammation anxiety. SP (2.0, 10.0 ...[more]

PMID: 32019580

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Dataset Information

Scopoletin ameliorates anxiety-like behaviors in complete Freund's adjuvant-induced mouse model.

Publications

Scopoletin ameliorates anxiety-like behaviors in complete Freund's adjuvant-induced mouse model.

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