Ontology highlight
ABSTRACT:
SUBMITTER: Dold A
PROVIDER: S-EPMC7001992 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Dold Annabelle A Han Hong H Liu Niankun N Hildebrandt Andrea A Brüggemann Mirko M Rücklé Cornelia C Hänel Heike H Busch Anke A Beli Petra P Zarnack Kathi K König Julian J Roignant Jean-Yves JY Lasko Paul P
PLoS genetics 20200124 1
Makorins are evolutionary conserved proteins that contain C3H-type zinc finger modules and a RING E3 ubiquitin ligase domain. In Drosophila, maternal Makorin 1 (Mkrn1) has been linked to embryonic patterning but the mechanism remained unsolved. Here, we show that Mkrn1 is essential for axis specification and pole plasm assembly by translational activation of oskar (osk). We demonstrate that Mkrn1 interacts with poly(A) binding protein (pAbp) and binds specifically to osk 3' UTR in a region adjac ...[more]