Ontology highlight
ABSTRACT:
SUBMITTER: Tsurugizawa T
PROVIDER: S-EPMC7002125 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Tsurugizawa Tomokazu T Tamada Kota K Ono Nobukazu N Karakawa Sachise S Kodama Yuko Y Debacker Clement C Hata Junichi J Okano Hideyuki H Kitamura Akihiko A Zalesky Andrew A Takumi Toru T
Science advances 20200205 6
MRI has potential as a translational approach from rodents to humans. However, given that mouse functional MRI (fMRI) uses anesthetics for suppression of motion, it has been difficult to directly compare the result of fMRI in "unconsciousness" disease model mice with that in "consciousness" patients. We develop awake fMRI to investigate brain function in <i>15q dup</i> mice, a copy number variation model of autism. Compared to wild-type mice, we find that <i>15q dup</i> is associated with whole- ...[more]