Ontology highlight
ABSTRACT:
SUBMITTER: Shmukler BE
PROVIDER: S-EPMC7002294 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Shmukler Boris E BE Rivera Alicia A Bhargava Parul P Nishimura Katherine K Kim Edward H EH Hsu Ann A Wohlgemuth Jay G JG Morton James J Snyder L Michael LM De Franceschi Lucia L Rust Marco B MB Hubner Christian A CA Brugnara Carlo C Alper Seth L SL
Blood cells, molecules & diseases 20191125
β-thalassemia (β-Thal) is caused by defective β-globin production leading to globin chain imbalance, aggregation of free alpha chain in developing erythroblasts, reticulocytes, and mature circulating red blood cells. The hypochromic thalassemic red cells exhibit increased cell dehydration in association with elevated K<sup>+</sup> leak and increased K-Cl cotransport activity, each of which has been linked to globin chain imbalance and related oxidative stress. We therefore tested the effect of g ...[more]