Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate.
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ABSTRACT:
SUBMITTER: Takahashi H
PROVIDER: S-EPMC7002588 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate.
Takahashi Hideo H Asaoka Mariko M Yan Li L Rashid Omar M OM Oshi Masanori M Ishikawa Takashi T Nagahashi Masayuki M Takabe Kazuaki K
Scientific reports 20200205 1
While cancer cells gain aggressiveness by mutations, abundant mutations release neoantigens, attracting anti-cancer immune cells. We hypothesized that in breast cancer (BC), where mutation is less common, tumors with high mutation rates demonstrate aggressive phenotypes and attract immune cells simultaneously. High mutation rates were defined as the top 10% of the mutation rate, utilizing TCGA and METABRIC transcriptomic data. Mutation rate did not impact survival although high mutation BCs were ...[more]
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