Ontology highlight
ABSTRACT:
SUBMITTER: Horkova V
PROVIDER: S-EPMC7003063 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cell reports 20200201 5
Overtly self-reactive T cells are removed during thymic selection. However, it has been recently established that T cell self-reactivity promotes protective immune responses. Apparently, the level of self-reactivity of mature T cells must be tightly balanced. Our mathematical model and experimental data show that the dynamic regulation of CD4- and CD8-LCK coupling establish the self-reactivity of the peripheral T cell pool. The stoichiometry of the interaction between CD8 and LCK, but not betwee ...[more]