Ontology highlight
ABSTRACT:
SUBMITTER: Yan Y
PROVIDER: S-EPMC7003668 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yan Youyou Y Song Dandan D Wu Junduo J Wang Junnan J
Frontiers in immunology 20200130
Atherosclerosis is characterized as a chronic inflammatory response to cholesterol deposition in arteries. Low-density lipoprotein (LDL), especially the oxidized form (ox-LDL), plays a crucial role in the occurrence and development of atherosclerosis by inducing endothelial cell (EC) dysfunction, attracting monocyte-derived macrophages, and promoting chronic inflammation. However, the mechanisms linking cholesterol accumulation with inflammation in macrophage foam cells are poorly understood. Lo ...[more]