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Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study.

ABSTRACT: OBJECTIVE:To examine the association between maternal alcohol consumption during pregnancy and the risk of preterm delivery. DESIGN:Prospective cohort study. SETTING:The Japan Environment and Children's Study (JECS). POPULATION:A total of 94 349 singleton pregnancies. METHODS:Participants completed questionnaires detailing alcohol consumption during the first trimester and during the second and third trimesters. Participants were divided into four categories according to alcohol consumption (non-drinkers, consumers of 1-149 g, 150-299 g and ?300 g ethanol/week). We examined the effect of alcohol consumption during different stages of pregnancy on the risk of preterm delivery. Odds ratios (OR) and 95% CI were calculated relative to non-drinkers using logistic regression. MAIN OUTCOME MEASURES:Medical record-based preterm delivery. RESULTS:Alcohol consumption during the second and third trimesters, but not during the first trimester, was associated with increased risk of preterm delivery. Heavy alcohol consumption (?300 g ethanol/week) during the second and third trimesters was associated with a four-fold higher risk compared with non-drinkers (multivariable OR 4.52; 95% CI 1.68-12.2). Light alcohol consumption (1-149 g ethanol/week) tended to be associated with lower risk of preterm delivery (multivariable OR 0.78; 95% CI 0.60-1.00). CONCLUSIONS:Heavy alcohol consumption during the second and third trimesters was associated with increased risk of preterm delivery among pregnant women. TWEETABLE ABSTRACT:Heavy drinking during pregnancy may increase the risk of preterm delivery.

SUBMITTER: Ikehara S

PROVIDER: S-EPMC7003893 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study.

Ikehara S S Kimura T T Kakigano A A Sato T T Iso H H

BJOG : an international journal of obstetrics and gynaecology 20190825 12

<h4>Objective</h4>To examine the association between maternal alcohol consumption during pregnancy and the risk of preterm delivery.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>The Japan Environment and Children's Study (JECS).<h4>Population</h4>A total of 94 349 singleton pregnancies.<h4>Methods</h4>Participants completed questionnaires detailing alcohol consumption during the first trimester and during the second and third trimesters. Participants were divided into four categories a ...[more]

PMID: 31386246

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Project description:BackgroundThe association between fetal exposure to alcohol and congenital structural disorders remains inconclusive. The present study searched for relationships between maternal alcohol consumption during pregnancy and the risk of congenital malformations.MethodsWe evaluated the fixed dataset of a large national birth cohort study including 73,595 mothers with a singleton live birth. Information regarding the alcohol consumption of mothers was obtained from self-reported questionnaires. Physicians assessed for 6 major congenital malformations (congenital heart defects [CHDs], male genital abnormalities, limb defects, cleft lip and/or cleft palate [orofacial clefts (OFC)], severe brain abnormalities, and gastrointestinal obstructions) up to 1 month after birth. Multiple logistic regression analysis was performed to identify associations between maternal alcohol consumption during pregnancy and each malformation.ResultsThe prevalence of maternal drinking in early pregnancy and until the second/third trimester was 46.6% and 2.8%, respectively. The onset of CHD was inversely associated with mothers who quit drinking during early pregnancy (OR 0.85, 95% CI 0.74-0.98). There was no remarkable impact of maternal drinking habit status on the other congenital malformations after adjustment for covariates.ConclusionsMaternal alcohol consumption during pregnancy, even in early pregnancy, displayed no significant adverse impact on congenital malformations of interest.ImpactThis large-scale Japanese cohort study revealed that no teratogenic associations were found between maternal retrospective reports of periconceptional alcohol consumption and congenital malformations after adjustment for covariates. This is the first nationwide birth cohort study in Japan to assess the effect of maternal alcohol consumption during pregnancy on major congenital malformations. Our finding indicated that maternal low-to-moderate alcohol consumption during pregnancy, even in early pregnancy, displayed no significant adverse impact on congenital heart defects, male genital abnormalities, limb defects, orofacial clefts, severe brain abnormalities, or gastrointestinal obstructions.

Dataset Information

Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study.

Publications

Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study.

Similar Datasets

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