GPER-induced signaling is essential for the survival of breast cancer stem cells.
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ABSTRACT:
SUBMITTER: Chan YT
PROVIDER: S-EPMC7003894 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
GPER-induced signaling is essential for the survival of breast cancer stem cells.
Chan Yu-Tzu YT Lai Alan C-Y AC Lin Ruey-Jen RJ Wang Ya-Hui YH Wang Yi-Ting YT Chang Wen-Wei WW Wu Hsin-Yi HY Lin Yu-Ju YJ Chang Wen-Ying WY Wu Jen-Chine JC Yu Jyh-Cherng JC Chen Yu-Ju YJ Yu Alice L AL
International journal of cancer 20190807 6
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patient-derived xenografts of ER<sup>-</sup> /PR<sup>+</sup> breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammo ...[more]
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