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Multidimensional diffusion processes in dynamic online networks.

ABSTRACT: We develop a dynamic matched sample estimation algorithm to distinguish peer influence and homophily effects on item adoption decisions in dynamic networks, with numerous items diffusing simultaneously. We infer preferences using a machine learning algorithm applied to previous adoption decisions, and we match agents using those inferred preferences. We show that ignoring previous adoption decisions leads to significantly overestimating the role of peer influence in the diffusion of information, mistakenly confounding influence-based contagion with diffusion driven by common preferences. Our matching-on-preferences algorithm with machine learning reduces the relative effect of peer influence on item adoption decisions in this network significantly more than matching on earlier adoption decisions, as well other observable characteristics. We also show significant and intuitive heterogeneity in the relative effect of peer influence.

SUBMITTER: Easley D

PROVIDER: S-EPMC7004299 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Multidimensional diffusion processes in dynamic online networks.

Easley David D Patacchini Eleonora E Rojas Christopher C

PloS one 20200206 2

We develop a dynamic matched sample estimation algorithm to distinguish peer influence and homophily effects on item adoption decisions in dynamic networks, with numerous items diffusing simultaneously. We infer preferences using a machine learning algorithm applied to previous adoption decisions, and we match agents using those inferred preferences. We show that ignoring previous adoption decisions leads to significantly overestimating the role of peer influence in the diffusion of information, ...[more]

PMID: 32027659

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Project description:Background and objectiveCOVID-19 severity spans an entire clinical spectrum from asymptomatic to fatal. Most patients who require in-hospital care are admitted to non-intensive wards, but their clinical conditions can deteriorate suddenly and some eventually die. Clinical data from patients' case series have identified pre-hospital and in-hospital risk factors for adverse COVID-19 outcomes. However, most prior studies used static variables or dynamic changes of a few selected variables of interest. In this study, we aimed at integrating the analysis of time-varying multidimensional clinical-laboratory data to describe the pathways leading to COVID-19 outcomes among patients initially hospitalised in a non-intensive care setting.MethodsWe collected the longitudinal retrospective data of 394 patients admitted to non-intensive care units at the University Hospital of Padova (Padova, Italy) due to COVID-19. We trained a dynamic Bayesian network (DBN) to encode the conditional probability relationships over time between death and all available demographics, pre-existing conditions, and clinical laboratory variables. We applied resampling, dynamic time warping, and prototyping to describe the typical trajectories of patients who died vs. those who survived.ResultsThe DBN revealed that the trajectory linking demographics and pre-existing clinical conditions to death passed directly through kidney dysfunction or, more indirectly, through cardiac damage. As expected, admittance to the intensive care unit was linked to markers of respiratory function. Notably, death was linked to elevation in procalcitonin and D-dimer levels. Death was associated with persistently high levels of procalcitonin from admission and throughout the hospital stay, likely reflecting bacterial superinfection. A sudden raise in D-dimer levels 3-6 days after admission was also associated with subsequent death, possibly reflecting a worsening thrombotic microangiopathy.ConclusionsThis innovative application of DBNs and prototyping to integrated data analysis enables visualising the patient's trajectories to COVID-19 outcomes and may instruct timely and appropriate clinical decisions.

Dataset Information

Multidimensional diffusion processes in dynamic online networks.

Publications

Multidimensional diffusion processes in dynamic online networks.

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