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The feasibility and acceptability of research magnetic resonance imaging in adolescents with moderate-severe neuropathic pain.

ABSTRACT: Introduction:Multimodal characterisation with questionnaires, Quantitative Sensory Testing (QST), and neuroimaging will improve understanding of neuropathic pain (NeuP) in adolescents. Magnetic resonance imaging (MRI) data in adolescents with NeuP are limited, and the perceived practical or ethical burden of scanning may represent a barrier to research. Objective:To determine the feasibility of MRI scanning in adolescents with moderate-severe NeuP, with respect to consent rate, postscan acceptability, and data quality. Methods:This prospective cohort study evaluating questionnaires and QST recruited adolescents aged 10 to 18 years with clinically diagnosed NeuP from a tertiary clinic. Eligible adolescents aged 11 years and older could additionally agree/decline an MRI scan. After the scan, families rated discomfort, perceived risk, and acceptability of current and future MRI scans (0-10 numerical rating scales). Head motion during scanning was compared with healthy controls to assess data quality. Results:Thirty-four families agreed to MRI (72% recruitment), and 21 adolescents with moderate-severe pain (average last week 6.7 ± 1.7; mean ± SD) and with neuropathic QST profiles were scanned. Three adolescents reported positional or noise-related discomfort during scanning. Perceived risk was low, and acceptability of the current scan was high for parents (range [median]: 7 to 10/10 [10]) and adolescents (8-10/10 [10]). Willingness to undergo a future research scan was high for parents (7-10/10 [10]) and adolescents (5-10/10 [10]) and did not differ from future scans for clinical purposes. Mean head motion during resting state functional MRI did not differ from control adolescents. Conclusion:Research MRI is feasible and acceptable for many adolescents with moderate-severe NeuP.

SUBMITTER: Verriotis M

PROVIDER: S-EPMC7004507 | biostudies-literature | 2020 Jan-Feb

REPOSITORIES: biostudies-literature

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The feasibility and acceptability of research magnetic resonance imaging in adolescents with moderate-severe neuropathic pain.

Verriotis Madeleine M Moayedi Massieh M Sorger Clarissa C Peters Judy J Seunarine Kiran K Clark Christopher A CA Walker Suellen M SM

Pain reports 20200121 1

<h4>Introduction</h4>Multimodal characterisation with questionnaires, Quantitative Sensory Testing (QST), and neuroimaging will improve understanding of neuropathic pain (NeuP) in adolescents. Magnetic resonance imaging (MRI) data in adolescents with NeuP are limited, and the perceived practical or ethical burden of scanning may represent a barrier to research.<h4>Objective</h4>To determine the feasibility of MRI scanning in adolescents with moderate-severe NeuP, with respect to consent rate, po ...[more]

PMID: 32072101

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Project description:BackgroundMagnetic Resonance-guided Focused Ultrasound (MRgFUS) is an innovative therapeutical approach for medically refractory tremor. It is currently under investigation for other neurological diseases including refractory neuropathic pain (NP).ObjectiveThe objective of this systematic review is to analyze available evidence about the effectiveness and safety profile of MRgFUS in the treatment of refractory NP.MethodsEligible studies were identified by searching published studies in PubMed and Scopus databases from inception to December 2022 and by identifying ongoing studies registered on the clinicaltrials.gov website. The study was registered in PROSPERO (ID: CRD42021277154).ResultsWe found three published observational studies and nine ongoing studies. In published studies, the involved population ranged from 8 to 46 patients with overall 66 patients being included with NP or trigeminal neuralgia. The target lesion was in the posterior part of the central lateral nucleus of the thalamus, bilaterally. Outcomes were assessed at different times through the Visual Analog Scale, showing a variable degree of improvement. Adverse events were rare, mild, and transient (vertigo, paresthesias, and dysesthesias) with intracerebral bleeding being reported as major adverse event in one case only. Among ongoing studies, we found three prospective, randomized, sham-controlled, crossover trials (RCTs) and six observational studies. Inclusion criteria are previous failure of more than three pharmacological treatments and NP duration longer than 6 months. The thalamus is the main proposed target and measured outcomes are accuracy of the procedure and pain relief, with a follow-up period ranging from 1 week to 1 year.ConclusionThis systematic review suggests that, although high-quality studies are lacking, available evidence endorses the effectiveness and safety of MRgFUS in the management of NP. Ongoing RCTs will provide more robust data to understand benefits and risks of the procedure.RegistrationPROSPERO (ID: CRD42021277154).

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The feasibility and acceptability of research magnetic resonance imaging in adolescents with moderate-severe neuropathic pain.

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The feasibility and acceptability of research magnetic resonance imaging in adolescents with moderate-severe neuropathic pain.

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