CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer.
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ABSTRACT:
SUBMITTER: Zheng Q
PROVIDER: S-EPMC7004517 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer.
Zheng Qianqian Q Gao Jian J Yin Ping P Wang Wei W Wang Biao B Li Yan Y Zhao Chenghai C
Cancer science 20200102 2
Patients with triple-negative breast cancer (TNBC) lack molecular targets and have an unfavorable outcome. CD155 is overexpressed in human cancers, but whether it plays a role in TNBC is unexplored. Here we found that CD155 was enriched in both TNBC cell lines and tumor tissues. High CD155 expression was related to poor prognosis of breast cancer patients. CD155 was associated with a mesenchymal phenotype. CD155 knockdown induced a mesenchymal-epithelial transition in TNBC cells, and suppressed ...[more]
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