Ontology highlight
ABSTRACT:
SUBMITTER: Sun Z
PROVIDER: S-EPMC7004864 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Sun Zhuyezi Z Wakefield Amanda Elizabeth AE Kolossvary Istvan I Beglov Dmitri D Vajda Sandor S
Structure (London, England : 1993) 20191203 2
Many proteins in their unbound structures have cryptic sites that are not appropriately sized for drug binding. We consider here 32 proteins from the recently published CryptoSite set with validated cryptic sites, and study whether the sites remain cryptic in all available X-ray structures of the proteins solved without any ligand bound near the sites. It was shown that only few of these proteins have binding pockets that never form without ligand binding. Sites that are cryptic in some structur ...[more]