Ontology highlight
ABSTRACT:
SUBMITTER: Cunningham JM
PROVIDER: S-EPMC7004877 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature methods 20200106 2
In mammalian cells, much of signal transduction is mediated by weak protein-protein interactions between globular peptide-binding domains (PBDs) and unstructured peptidic motifs in partner proteins. The number and diversity of these PBDs (over 1,800 are known), their low binding affinities and the sensitivity of binding properties to minor sequence variation represent a substantial challenge to experimental and computational analysis of PBD specificity and the networks PBDs create. Here, we intr ...[more]