Project description:Background and study aims ?Endoscopic and surgical techniques have been utilized for palliation of gastric outlet obstruction (GOO). Enteral stenting (ES) is an established technique with high clinical success and low morbidity rate. Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a novel approach that aims to provide sustained palliation of GOO. We conducted a comprehensive review and meta-analysis to evaluate the effectiveness in terms of clinical and technical success, as well as the safety profile of EUS-GE and ES. Methods ?We searched multiple databases from inception through July 2020 to identify studies that reported on safety and effectiveness of EUS-GE in comparison to ES.?Pooled rates of technical success, clinical success, and adverse events (AEs) were calculated. Study heterogeneity was assessed using I 2 % and 95?% confidence interval. Results ?Five studies including 659 patients were included in our final analysis. Pooled rate of technical and clinical success for EUS-GE was 95.2?% (CI 87.2-.98.3, I 2 ?=?42) and 93.3?% (CI 84.4-97.3, I 2 ?=?59) while for ES it was 96.9?% (CI 90.9-99, I 2 ?=?64) and 85.6?% (CI 73-92.9, I 2 ?=?85), respectively. Pooled rate of re-intervention was significantly lower with EUS-GE i.?e. 4?% (CI 1.8-8.7, I 2 ?=?35) compared to ES, where it was 23.6?% (CI 17.5-31, I 2 ?=?35), p?=?0.001 . Pooled rates of overall and major AEs were comparable between the two techniques. Conclusion ?EUS-GE is comparable in terms of technical and clinical effectiveness and has a similar safety profile when compared to ES for palliation of GOO.

| S-EPMC7899789 | biostudies-literature

EUS-guided gastroenterostomy in a COVID-19-infected patient with duodenal stenosing lymphoma (with videos).

Project description: Not available

| S-EPMC8248301 | biostudies-literature

EUS-guided gastroenterostomy for relief of obstructive symptoms in a patient with a large Bochdalek hernia.

Project description: Not available

| S-EPMC7730137 | biostudies-literature

Efficacy and safety of EUS-guided gastroenterostomy for benign and malignant gastric outlet obstruction: a systematic review and meta-analysis.

Project description:Background and study aims? Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a novel endoscopic procedure designed to facilitate sustained luminal patency in patients with gastric outlet obstruction. The primary aim of this study was to evaluate the efficacy and safety of EUS-GE for treatment of gastric outlet obstruction. Methods? Searches of PubMed, EMBASE, Web of Science, and Cochrane Library databases were performed through April 2019. Patients with benign and malignant gastric outlet obstruction were included. Measured outcomes included: immediate technical and clinical success as well as rate of serious adverse events (AEs). Heterogeneity was assessed with Cochran Q test and I 2 statistics. Publication bias was ascertained by funnel plot and Egger regression testing. Results? A total of five studies (n?=?199 patients; 45.73?% male) were included in this study. Four retrospective studies and one prospective study were analyzed. Mean age of patients that underwent the EUS-GE procedure was 64.52?±?1.37 years with a pooled mean follow-up period of 4.32?±?1.65 months. In 21?% of patients (n?=?43), gastric outlet obstruction was due to benign causes. Immediate technical success was 92.90?% (95?% CI; 88.26?-?95.79; I 2 ?=?0.00?%) and reported in all studies. The clinical success rate of EUS-GE was 90.11?% (95?% CI; 84.64?-?93.44; I 2 ?=?0.00?%). Serious AEs occurred in 5.61?% (95?% CI; 2.87?-?10.67; I 2 ?=?1.67?%) of cases and were related to peritonitis, perforation, bleeding, and abdominal pain. Re-intervention rate was 11.43?% (95?% CI; 7.29?-?17.46; I 2 ?=?17.38?%). Conclusions? EUS-GE appears to provide an effective and safe minimally invasive alternative for treatment of benign and malignant gastric outlet obstruction.

| S-EPMC6811354 | biostudies-literature

EUS-guided gastroenterostomy assisted by extrinsic abdominal compression to treat gastric obstruction after surgical resection of a GI stromal tumor.

Project description: Not available

| S-EPMC7859557 | biostudies-literature