Ontology highlight
ABSTRACT:
SUBMITTER: Ballweg S
PROVIDER: S-EPMC7005026 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature communications 20200206 1
Cells maintain membrane fluidity by regulating lipid saturation, but the molecular mechanisms of this homeoviscous adaptation remain poorly understood. We have reconstituted the core machinery for regulating lipid saturation in baker's yeast to study its molecular mechanism. By combining molecular dynamics simulations with experiments, we uncover a remarkable sensitivity of the transcriptional regulator Mga2 to the abundance, position, and configuration of double bonds in lipid acyl chains, and ...[more]